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Submit ReviewEicosapentaenoic Acid
Description: Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation
Chemical Name: (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic acid
Purity: ≥98%
Biological Activity for Eicosapentaenoic Acid
Endogenous polyunsaturated fatty acid. Stimulates ERK1/2 and C/EBPβ phosphorylation, and induces demethylation of CpG island B in U937 leukemia cells. Attenuates proliferation of U9137 cells, and induces cell cycle arrest and apoptosis in pancreatic cells in vitro. Also inhibits leukotriene B4 synthesis in rats.
Technical Data for Eicosapentaenoic Acid
| M. Wt | 302.45 |
| Formula | C20H30O2 |
| Storage | Store at -20°C |
| Purity | ≥98% |
| CAS Number | 10417-94-4 |
| PubChem ID | 446284 |
| InChI Key | JAZBEHYOTPTENJ-JLNKQSITSA-N |
| Smiles | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Eicosapentaenoic Acid
References for Eicosapentaenoic Acid
References are publications that support the biological activity of the product.
Ceccarelli et al (2014) Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One 9 e85025 PMID: 24454781
James et al (1993) Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: a novel approach to inhibition of eicosanoid synthesis. J.Exp.Med. 178 2261 PMID: 8245797
Lai et al (1996) Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br.J.Cancer 74 1375 PMID: 8912532
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Citations for Eicosapentaenoic Acid
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Currently there are no citations for Eicosapentaenoic Acid.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for Eicosapentaenoic Acid
