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Submit ReviewEIDD 1931
Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside
Chemical Name: N-Hydroxycytidine
Purity: ≥98% (HPLC)
Biological Activity for EIDD 1931
EIDD 1931 is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. Inhibits replication of a range of RNA viruses including influenza, Ebola, HCV, and human and zoonotic coronaviruses (IC50 values are 0.15 and 0.3 μM for inhibition of MERS-CoV and SARS-CoV-2 replication in vitro). Increases mutation rates and induces lethal mutagenesis in viral RNA. Also inhibits replication of mouse hepatitis virus with mutations conferring resistance to remdesivir (Cat. No. 7226).
Compound Libraries for EIDD 1931
EIDD 1931 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for EIDD 1931
| M. Wt | 259.22 |
| Formula | C9H13N3O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 3258-02-4 |
| PubChem ID | 197020 |
| InChI Key | XCUAIINAJCDIPM-XVFCMESISA-N |
| Smiles | OC[C@H]1O[C@@H](N2C=C/C(NC2=O)=N\O)[C@@H]([C@@H]1O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EIDD 1931
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.92 | 100 | |
| water | 12.96 | 50 |
Preparing Stock Solutions for EIDD 1931
The following data is based on the product molecular weight 259.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.86 mL | 19.29 mL | 38.58 mL |
| 5 mM | 0.77 mL | 3.86 mL | 7.72 mL |
| 10 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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Product Datasheets for EIDD 1931
References for EIDD 1931
References are publications that support the biological activity of the product.
Urakova et al (2018) β-d-N4-hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J.Virol. 92 PMID: 29167335
Sheahan et al (2020) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci.Transl.Med. 12 PMID: 32253226
If you know of a relevant reference for EIDD 1931, please let us know.
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Citations for EIDD 1931
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