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Submit ReviewFatostatin A
Description: Cell permeable inhibitor of SREBP activation
Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
Purity: ≥97% (HPLC)
Biological Activity for Fatostatin A
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.
Compound Libraries for Fatostatin A
Fatostatin A is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Fatostatin A
| M. Wt | 375.33 |
| Formula | C18H18N2S.HBr |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 298197-04-3 |
| PubChem ID | 2850562 |
| InChI Key | RJCFNQZVFUMORB-UHFFFAOYSA-N |
| Smiles | CCCC1=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=CC=N1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fatostatin A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.51 | 20 |
Preparing Stock Solutions for Fatostatin A
The following data is based on the product molecular weight 375.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.32 mL | 66.61 mL | 133.22 mL |
| 1 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 2 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
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Product Datasheets for Fatostatin A
References for Fatostatin A
References are publications that support the biological activity of the product.
Kamisuki et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882 PMID: 19716478
Choi et al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320 PMID: 12496288
If you know of a relevant reference for Fatostatin A, please let us know.
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Keywords: Fatostatin A, Fatostatin A supplier, sterol, regulatory, element, binding, proteins, SREBPs, SREBP1, SREBP2, inhibition, inhibitors, inhibits, antiproliferatives, 125B11, FatostatinA, SREBP, 4444, Tocris Bioscience
7 Citations for Fatostatin A
Citations are publications that use Tocris products. Selected citations for Fatostatin A include:
Keith S et al (2021) Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production. Sci Rep 11 16347 PMID: 34381163
Roche et al (2018) Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol 217 3560 PMID: 30054450
Uma Kant et al (2015) Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. J Biol Chem 290 9571-87 PMID: 25720493
Csaba et al (2019) Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs. Cell Stem Cell 25 120-136.e10 PMID: 31155483
Tania et al (2019) The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. Immunity 51 241-257.e9 PMID: 31303399
Xuejun et al (2020) Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. Proc Natl Acad Sci U S A 117 31189-31197 PMID: 33229547
Almut et al (2020) mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis. Cell Rep 31 107806 PMID: 32579932
Do you know of a great paper that uses Fatostatin A from Tocris? Please let us know.
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Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Pathways for Fatostatin A
