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Submit ReviewFavipiravir
Description: Viral RNA polymerase inhibitor
Alternative Names: T 705
Chemical Name: 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for Favipiravir
Favipiravir is a viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 cells in vitro (IC50 = 61.88 μM). Inhibits influenza virus RNA-dependent RNA polymerase (RdRP) activity (IC50 = 341 nM). Induces lethal mutagenesis in MDCK cells inoculated with seasonal influenza A (H1N1) viruses. Protects mice against Ebola virus.
Compound Libraries for Favipiravir
Favipiravir is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for Favipiravir
| M. Wt | 157.1 |
| Formula | C5H4FN3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 259793-96-9 |
| PubChem ID | 492405 |
| InChI Key | ZCGNOVWYSGBHAU-UHFFFAOYSA-N |
| Smiles | NC(C1=NC(F)=CNC1=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Favipiravir
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.71 | 100 | |
| ethanol | 3.14 | 20 |
Preparing Stock Solutions for Favipiravir
The following data is based on the product molecular weight 157.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.37 mL | 31.83 mL | 63.65 mL |
| 5 mM | 1.27 mL | 6.37 mL | 12.73 mL |
| 10 mM | 0.64 mL | 3.18 mL | 6.37 mL |
| 50 mM | 0.13 mL | 0.64 mL | 1.27 mL |
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Product Datasheets for Favipiravir
References for Favipiravir
References are publications that support the biological activity of the product.
Wang et al (2020) Remdesivir and Chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30 269 PMID: 32020029
Furuta et al (2002) In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob.Agents Chemother. 46 977 PMID: 11897578
If you know of a relevant reference for Favipiravir, please let us know.
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Keywords: Favipiravir, Favipiravir supplier, T705, Viral, RNA, polymerase, inhibitors, inhibits, antiviral, influenza, ebola, covid-19, T, 705, Polymerase, Influenza, Viruses, Coronavirus, 7225, Tocris Bioscience
Citations for Favipiravir
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