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Submit ReviewFlunarizine dihydrochloride
Discontinued Product
0522 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Dual Na+/Ca2+ channel (T-type) blocker
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Biological Activity for Flunarizine dihydrochloride
Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
Technical Data for Flunarizine dihydrochloride
| M. Wt | 477.42 |
| Formula | C26H26F2N2.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 30484-77-6 |
| PubChem ID | 5282407 |
| InChI Key | RXKMOPXNWTYEHI-RDRKJGRWSA-N |
| Smiles | Cl[H].Cl[H].FC1=CC=C(C=C1)C(N1CCN(C\C=C\C2=CC=CC=C2)CC1)C1=CC=C(F)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Flunarizine dihydrochloride
References for Flunarizine dihydrochloride
References are publications that support the biological activity of the product.
Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223
Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunar. Life.Sci. 48 1881 PMID: 1850815
Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246
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Keywords: Flunarizine dihydrochloride, Flunarizine dihydrochloride supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Voltage-gated, Cav3.x, 0522, Tocris Bioscience
Citations for Flunarizine dihydrochloride
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Currently there are no citations for Flunarizine dihydrochloride.
Reviews for Flunarizine dihydrochloride
Average Rating: 4 (Based on 1 Review.)
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Pharmacological manipulation of neuronal activity.
By
Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: primary neurons
To alter neuronal activity in vitro.