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Description: Ubiquitin isopeptidase inhibitor; induces apoptosis
Chemical Name: Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one-1,1-dioxide
Purity: ≥98% (HPLC)
Biological Activity for G5
G5 is an ubiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.
Technical Data for G5
| M. Wt | 414.39 |
| Formula | C19H14N2O7S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 108477-18-5 |
| PubChem ID | 5918438 |
| InChI Key | SSAMIOWVUGBIJK-KAVGSWPWSA-N |
| Smiles | O=C1/C(CS(=O)(C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=O)=C/C3=CC=C([N+]([O-])=O)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for G5
References for G5
References are publications that support the biological activity of the product.
Hafner-Bratkovic et al (2018) NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat.Commun. 9 5182 PMID: 30518920
Foti et al (2009) Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system. Mol.Cancer Ther. 8 3140 PMID: 19887551
Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768
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Keywords: G5, G5 supplier, Ubiquitin, isopeptidases, inhibitors, inhibits, caspases, activators, apoptosis, inducers, Deubiquitinating, Enzymes, Apoptosis, Inducers, 6776, Tocris Bioscience
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