G5

Discontinued Product

6776 has been discontinued.

View all Deubiquitinating Enzymes products.
Description: Ubiquitin isopeptidase inhibitor; induces apoptosis
Chemical Name: Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one-1,1-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for G5

G5 is an ubiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.

Technical Data for G5

M. Wt 414.39
Formula C19H14N2O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 108477-18-5
PubChem ID 5918438
InChI Key SSAMIOWVUGBIJK-KAVGSWPWSA-N
Smiles O=C1/C(CS(=O)(C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=O)=C/C3=CC=C([N+]([O-])=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for G5

References are publications that support the biological activity of the product.

Hafner-Bratkovic et al (2018) NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat.Commun. 9 5182 PMID: 30518920

Foti et al (2009) Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system. Mol.Cancer Ther. 8 3140 PMID: 19887551

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768

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Keywords: G5, G5 supplier, Ubiquitin, isopeptidases, inhibitors, inhibits, caspases, activators, apoptosis, inducers, Deubiquitinating, Enzymes, Apoptosis, Inducers, 6776, Tocris Bioscience

Citations for G5

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Currently there are no citations for G5.

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