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Submit ReviewGM 6001
Description: Broad spectrum MMP inhibitor
Alternative Names: Galardin,Ilomastat
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
Purity: ≥95% (HPLC)
Biological Activity for GM 6001
GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
Technical Data for GM 6001
| M. Wt | 388.46 |
| Formula | C20H28N4O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 142880-36-2 |
| PubChem ID | 132519 |
| InChI Key | NITYDPDXAAFEIT-DYVFJYSZSA-N |
| Smiles | O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC2=CNC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GM 6001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.85 | 100 |
Preparing Stock Solutions for GM 6001
The following data is based on the product molecular weight 388.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.87 mL | 25.74 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.15 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets for GM 6001
References for GM 6001
References are publications that support the biological activity of the product.
Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701 PMID: 21602423
Grobelny et al (1992) Inhibition of skin fibroblast Col., thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152 PMID: 1322694
Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49 PMID: 17678888
If you know of a relevant reference for GM 6001, please let us know.
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Keywords: GM 6001, GM 6001 supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin, Matrix, Metalloprotease, 2983, Tocris Bioscience
10 Citations for GM 6001
Citations are publications that use Tocris products. Selected citations for GM 6001 include:
Bras et al (2015) TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. PLoS One 330 29 PMID: 25064463
Greene et al (2015) CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells. Proc Natl Acad Sci U S A 10 e0144133 PMID: 26710229
Luo et al (2018) Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nat Commun 9 4126 PMID: 30297691
Kim et al (2018) Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun 9 4600 PMID: 30389913
Conant et al (2017) Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation 14 56 PMID: 28302163
Son et al (2015) STAT induce Ins-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener 10 56 PMID: 26520569
Sun et al (2017) Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem 41 2319 PMID: 28463834
Lahey et al (2017) Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS One 12 e0180259 PMID: 28671992
Schumacher (2017) ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis 8 e2622 PMID: 28230865
Leung et al (2015) PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol 194 2930 PMID: 25687758
Do you know of a great paper that uses GM 6001 from Tocris? Please let us know.
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