Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewHBX 41108
Description: Selective USP7 inhibitor
Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Purity: ≥98% (HPLC)
Biological Activity for HBX 41108
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
Licensing Information
Sold for research use only under patent license from Hybrigenics S.A.
Technical Data for HBX 41108
| M. Wt | 266.64 |
| Formula | C13H3ClN4O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 924296-39-9 |
| PubChem ID | 16065773 |
| InChI Key | BIGPXXAUSQLTQR-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC(Cl)=CC=C1C3=C2N=C(C#N)C(C#N)=N3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HBX 41108
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.66 | 100 |
Preparing Stock Solutions for HBX 41108
The following data is based on the product molecular weight 266.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.75 mL | 37.5 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.5 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for HBX 41108
References for HBX 41108
References are publications that support the biological activity of the product.
Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286 PMID: 19671755
Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552 PMID: 20186914
If you know of a relevant reference for HBX 41108, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: HBX 41108, HBX 41108 supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, inhibits, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated, Deubiquitinating, Enzymes, 4285, Tocris Bioscience
6 Citations for HBX 41108
Citations are publications that use Tocris products. Selected citations for HBX 41108 include:
Hesham et al (2020) TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts. J Cell Sci PMID: 34005169
Hesham et al (2020) TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts. J Cell Sci 133 PMID: 32434871
Benedikt M et al (2021) ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context. Front Chem 9 640105 PMID: 33718328
Ji et al (2019) USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin. Nat Commun 10 4184 PMID: 31519875
Tavana et al (2018) Targeting HAUSP in both p53 wildtype and p53-mutant tumors. Cell Cycle 1 PMID: 29616860
Yuda et al (2022) Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice. iScience 25 104595 PMID: 35800757
Do you know of a great paper that uses HBX 41108 from Tocris? Please let us know.
Reviews for HBX 41108
Average Rating: 5 (Based on 1 Review.)
Have you used HBX 41108?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
USP7 inhibitors 1 (HBX41108).
By
Anonymous on 12/10/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK293
HEK293T cells stably expressing the STF-Luc reporter were pretreated with increasing amounts of USP7 inhibitors HBX41108
