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Submit ReviewHelianorphin-19
Description: Potent and selective G protein-biased κ opioid receptor (KOR) agonist
Purity: ≥95% (HPLC)
Biological Activity for Helianorphin-19
Helianorphin-19 is a high affinity, potent and selective G protein-biased κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50 = 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors. In vivo Helianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.
Technical Data for Helianorphin-19
| M. Wt | 1790.21 |
| Formula | C81H132N26O16S2 |
| Sequence |
CYGGFLRRCIRPKLK (Modifications: Cyclic peptide, Disulfide bridge: 1-9] |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2883653-86-7 |
| InChI Key | WEJHFJXWIBZZTQ-AHUOXLFJSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)NC3=O)NC5=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Helianorphin-19
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Helianorphin-19
References for Helianorphin-19
References are publications that support the biological activity of the product.
Muratspahić et al (2021) Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. J.Med.Chem. 64 9042 PMID: 34162205
If you know of a relevant reference for Helianorphin-19, please let us know.
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Keywords: Helianorphin-19, Helianorphin-19 supplier, activates, opioid, kappa-opioid, agonists, agonism, KOP, Receptors, KOR, potent, selective, Kappa, Opioid, 7541, Tocris Bioscience
Citations for Helianorphin-19
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