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Submit ReviewHemokinin 1 (human)
Description: Endogenous and selective NK1 agonist
Biological Activity for Hemokinin 1 (human)
Hemokinin 1 (human) is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
Technical Data for Hemokinin 1 (human)
| M. Wt | 1185.4 |
| Formula | C54H84N14O14S |
| Sequence |
TGKASQFFGLM (Modifications: Met- 11= C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 491851-53-7 |
| PubChem ID | 71311766 |
| InChI Key | NYBLUYYRUFKGTB-XJCFQSCISA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Hemokinin 1 (human)
References for Hemokinin 1 (human)
References are publications that support the biological activity of the product.
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503
Kurtz et al (2002) Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 296 205 PMID: 12383518
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nature Immunol. 1 392
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Keywords: Hemokinin 1 (human), Hemokinin 1 (human) supplier, Endogenous, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (human), Receptor, 2576, Tocris Bioscience
Citations for Hemokinin 1 (human)
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Currently there are no citations for Hemokinin 1 (human).
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