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Submit ReviewHemokinin 1 (mouse)
Description: Endogenous, high affinity and selective NK1 agonist
Alternative Names: HK-1,HEK-1
Biological Activity for Hemokinin 1 (mouse)
Novel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
Technical Data for Hemokinin 1 (mouse)
| M. Wt | 1413.66 |
| Formula | C61H100N22O15S |
| Sequence |
RSRTRQFYGLM (Modifications: Met-11 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 208041-90-1 |
| PubChem ID | 90479800 |
| InChI Key | ZOLDEMZLDJFVRY-RULPZMNSSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Hemokinin 1 (mouse)
References for Hemokinin 1 (mouse)
References are publications that support the biological activity of the product.
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503
Morteau et al (2001) Hemokinin 1 is a full agonist at the substance P receptor. Nat.Immunol. 2 1088 PMID: 11725292
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat.Immunol. 1 392 PMID: 11062498
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Keywords: Hemokinin 1 (mouse), Hemokinin 1 (mouse) supplier, Endogenous, high, affinity, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (mouse), HK-1, HEK-1, Receptor, 1535, Tocris Bioscience
Citations for Hemokinin 1 (mouse)
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