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Submit ReviewHexa-D-arginine
Description: Furin inhibitor
Purity: ≥95% (HPLC)
Biological Activity for Hexa-D-arginine
Hexa-D-arginine is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
Technical Data for Hexa-D-arginine
| M. Wt | 954.16 |
| Formula | C36H75N25O6 |
| Sequence |
RRRRRR (Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6 = D-Arg) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 673202-67-0 |
| PubChem ID | 57358476 |
| InChI Key | BMLTZEAFQLJTIZ-TZNXUKFXSA-N |
| Smiles | [H]N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Hexa-D-arginine
References for Hexa-D-arginine
References are publications that support the biological activity of the product.
Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 28 56 PMID: 22886699
Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741 PMID: 10958789
Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239
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Keywords: Hexa-D-arginine, Hexa-D-arginine supplier, Hexa-D-arginine, selective, furin, inhibitors, inhibits, paired, basic, amino, acid, cleaving, enzyme, PACE, subtilisin-like, proprotein, convertases, Furin, 4711, Tocris Bioscience
2 Citations for Hexa-D-arginine
Citations are publications that use Tocris products. Selected citations for Hexa-D-arginine include:
Wang et al (2019) Biowire Model of Interstitial and Focal Cardiac Fibrosis. ACS Cent Sci 5 1146 PMID: 31403068
Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. PMID: 33007239
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