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Honokiol

Cat. No. 4590 2 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

4590 has been discontinued.

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Description: Blocks NF-κB activation; also anti-inflammatory and antioxidant
Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Honokiol

Honokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

Technical Data for Honokiol

M. Wt 266.33
Formula C18H18O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 35354-74-6
PubChem ID 72303
InChI Key FVYXIJYOAGAUQK-UHFFFAOYSA-N
Smiles OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Honokiol

References are publications that support the biological activity of the product.

Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113 PMID: 18158873

Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589 PMID: 18640101

Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621 PMID: 16966432

Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501 PMID: 12816951

Pillai et al (2015) Nat.Commun. 6 6656 PMID: 25871545

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Keywords: Honokiol, Honokiol supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, NF-kB/IkB, Antioxidants, Class, III, HDACs, (Sirtuins), 4590, Tocris Bioscience

2 Citations for Honokiol

Citations are publications that use Tocris products. Selected citations for Honokiol include:

Xu et al (2017) Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice. Dis Model Mech 10 1117 PMID: 28714852

Melitta et al (2022) Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci 23 PMID: 35457156

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Pathways for Honokiol

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.