Home / Cell Biology / Signal Transduction / Cytokine and NF-κB Signaling / NF-κB and IκB / NF-κB and IκB Inhibitors / Honokiol

Honokiol

Cat. No. 4590 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Blocks NF-κB activation; also anti-inflammatory and antioxidant
Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Honokiol

Honokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

Technical Data for Honokiol

M. Wt 266.33
Formula C18H18O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 35354-74-6
PubChem ID 72303
InChI Key FVYXIJYOAGAUQK-UHFFFAOYSA-N
Smiles OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Honokiol

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.63 100
ethanol 26.63 100

Preparing Stock Solutions for Honokiol

The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.77 mL 37.55 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Honokiol

References are publications that support the biological activity of the product.

Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113 PMID: 18158873

Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589 PMID: 18640101

Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621 PMID: 16966432

Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501 PMID: 12816951

Pillai et al (2015) Nat.Commun. 6 6656 PMID: 25871545

If you know of a relevant reference for Honokiol, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: Honokiol, Honokiol supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, NF-kB/IkB, Antioxidants, Class, III, HDACs, (Sirtuins), 4590, Tocris Bioscience

2 Citations for Honokiol

Citations are publications that use Tocris products. Selected citations for Honokiol include:

Xu et al (2017) Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice. Dis Model Mech 10 1117 PMID: 28714852

Melitta et al (2022) Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci 23 PMID: 35457156

Do you know of a great paper that uses Honokiol from Tocris? Please let us know.

Reviews for Honokiol

There are currently no reviews for this product. Be the first to review Honokiol and earn rewards!

Have you used Honokiol?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for Honokiol

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.