I 432

Cat. No. 7292 Submit a Review Datasheet / COA / SDS

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Description: TMPRSS2 Inhibitor

Chemical Name: 3-[(2S)-3-[4-(2-Aminoethyl)-1-piperidinyl]-2-[[(2',4'-dichloro[1,1'-biphenyl]-3-yl)sulfonyl]amino]-3-oxopropyl]benzenecarboximidamide ditrifluoroacetate

Purity: ≥98% (HPLC)

Datasheet

Citations

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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for I 432

I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (K_i =0.9 nM). It blocks influenza virus propagation in airway epithelial cells. In IPEC-J2 pig jejunal epithelial cells, I 432 (50 μM) inhibits TMPRSS2 without affecting cell viability after 48 h treatment.

Technical Data for I 432

M. Wt	830.62
Formula	C₂₉H₃₃Cl₂N₅O₃S.2CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1268874-09-4
InChI Key	HCTPOLRWOSFUBB-LPCSYZHESA-N
Smiles	NCCC1CCN(C([C@@H](NS(=O)(C2=CC=CC(C3=C(C=C(C=C3)Cl)Cl)=C2)=O)CC4=CC(C(N)=N)=CC=C4)=O)CC1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for I 432

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	83.06	100
	ethanol	83.06	100

Preparing Stock Solutions for I 432

The following data is based on the product molecular weight 830.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.2 mL	6.02 mL	12.04 mL
5 mM	0.24 mL	1.2 mL	2.41 mL
10 mM	0.12 mL	0.6 mL	1.2 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

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Product Datasheets for I 432

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for I 432

References are publications that support the biological activity of the product.

Meyer et al (2013) Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. Biochem J. 452 331 PMID: 23527573

Pászti-Gere et al (2016) In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. J.Enzyme Inhib.Med.Chem. 31 123 PMID: 27277342

Alexander et al (2020) A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. Br.J.Pharmacol. 177 4942 PMID: 32358833

If you know of a relevant reference for I 432, please let us know.

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Keywords: I 432, I 432 supplier, I432, inhibitors, inhibits, TMPRSS2, transmembrane, serine, proteinase, 2, influenza, viruses, Influenza, Viruses, 7292, Tocris Bioscience

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