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Submit ReviewICI 199,441 hydrochloride
Description: Potent κ agonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ICI 199,441 hydrochloride
ICI 199,441 hydrochloride is a highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries for ICI 199,441 hydrochloride
ICI 199,441 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ICI 199,441 hydrochloride
| M. Wt | 427.8 |
| Formula | C21H24Cl2N2O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115199-84-3 |
| PubChem ID | 3082717 |
| InChI Key | VFLWVWZSDBTGQJ-VEIFNGETSA-N |
| Smiles | ClC1=C(Cl)C=C(CC(N([C@@]([H])([C@]3=CC=CC=C3)CN2CCCC2)C)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ICI 199,441 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 | ||
| ethanol | 50 |
Preparing Stock Solutions for ICI 199,441 hydrochloride
The following data is based on the product molecular weight 427.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.69 mL | 23.38 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets for ICI 199,441 hydrochloride
References for ICI 199,441 hydrochloride
References are publications that support the biological activity of the product.
Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636
Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918
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Citations for ICI 199,441 hydrochloride
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