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Submit ReviewICI 204,448 hydrochloride
Description: κ agonist, acts peripherally
Chemical Name: (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ICI 204,448 hydrochloride
ICI 204,448 hydrochloride is a peripherally acting κ agonist.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ICI 204,448 hydrochloride
| M. Wt | 501.84 |
| Formula | C23H26Cl2N2O4.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 121264-04-8 |
| PubChem ID | 129407 |
| InChI Key | FNDGLVOYAQNQPE-UHFFFAOYSA-N |
| Smiles | Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ICI 204,448 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions for ICI 204,448 hydrochloride
The following data is based on the product molecular weight 501.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.96 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for ICI 204,448 hydrochloride
References for ICI 204,448 hydrochloride
References are publications that support the biological activity of the product.
Keïta et al (1995) Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 277 275 PMID: 7493620
Shaw et al (1989) ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 96 986 PMID: 2568146
If you know of a relevant reference for ICI 204,448 hydrochloride, please let us know.
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1 Citation for ICI 204,448 hydrochloride
Citations are publications that use Tocris products. Selected citations for ICI 204,448 hydrochloride include:
Butelman et al (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl) 210 253 PMID: 20084367
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Mouse EFS model.
By
John Broad on 01/05/2018
Assay Type: In Vitro
Species: Mouse
Inhibited mouse GI EFS smooth muscle contractions
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