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Description: Caspase-1 and NLRP3 inflammasome inhibitor
Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Purity: ≥98% (HPLC)
Biological Activity for INF 4E
INF 4E is a NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.
Technical Data for INF 4E
| M. Wt | 240.68 |
| Formula | C12H13ClO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 88039-46-7 |
| PubChem ID | 11402215 |
| InChI Key | BSRPDXCMAOIUOO-UHFFFAOYSA-N |
| Smiles | CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for INF 4E
| Solubility | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
Product Datasheets for INF 4E
References for INF 4E
References are publications that support the biological activity of the product.
Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID: 25418070
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Keywords: INF 4E, INF 4E supplier, INF4E, NLRP3, inflammasomes, caspases, 1, inhibitors, inhibits, pyroptosis, nrf2, Caspases, Inflammasomes, Nrf2, 6172, Tocris Bioscience
Citations for INF 4E
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Average Rating: 5 (Based on 1 Review.)
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The inhibitor can inhibit NLRP3 inflammasomes and block IL-1b production.
By
Xiaogang Wang on 09/15/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: THP-1
We used this product to study whether bacterial component can induce NLRP3-mediated IL-1beta production. To confirm whether this inhibitor works well, we pretreated THP-1 cells with the inhibitor for 1 h, followed by treatment with LPS+ATP for 2 h. The production of IL-1b in culture supernatant was measured by IL-1b ELISA kit. We showed that this inhibitor can significantly inhibit LPS/ATP-induced IL-1b production.
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