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Submit ReviewING-2 AM
Description: Fluorescent sodium ion (Na+) indicator, membrane permeable
Chemical Name: Bis(acetoxymethyl) 3,3'-(6-(acetoxymethoxy)-4,5-dichloro-9-(3-methoxy-4-(13-(2-methoxy-4-methylphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl)phenyl)-3-oxo-3H-xanthene-2,7-diyl)dipropionate
Purity: ≥90% (HPLC)
Biological Activity for ING-2 AM
ING-2 AM is a membrane-permeable fluorescent sodium ion (Na+) indicator. It binds to sodium (Kd = 20 mM). Excitation and emission maxima (λ) are 525 and 545 nm, respectively. It displays 20-fold selectivity over K+ ions. It is used in in vitro and in situ to detect real-time sodium influx.
It is recommended to prepare stock solutions in DMSO.
Optical Data for ING-2 AM
| λabs | 525 nm |
|---|---|
| λem | 545 nm |
| Cell Permeable | Yes |
| Application | Confocal microscopy, Flow cytometry, Two-photon microscopy |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for ING-2 AM
| M. Wt | 1083.96 |
| Formula | C53H60Cl2N2O18 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 1642554-49-1 |
| PubChem ID | 163341954 |
| InChI Key | OTIAVQNFWAJQKZ-UHFFFAOYSA-N |
| Smiles | O=C(C)OCOC(CCC1=CC2=C(C3=CC(OC)=C(N4CCOCCOCCN(CCOCC4)C5=CC=C(C)C=C5OC)C=C3)C6=C(C(Cl)=C(C(CCC(OCOC(C)=O)=O)=C6)OCOC(C)=O)OC2=C(C1=O)Cl)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ING-2 AM
References for ING-2 AM
References are publications that support the biological activity of the product.
Gregoriades et al (2019) Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter. Am.J.Physiol.Cell Physiol. 316 C525 PMID: 30576237
Blömer et al (2021) Ultrafast sodium imaging of the axon initial segment of neurons in mouse brain slices. Curr.Protoc. 1 e64 PMID: 33657273
Naumann et al (2018) Photophysical properties of Na+ -indicator dyes suitable for quantitative two-photon fluorescence-lifetime measurements. J.Microsc. 272 136 PMID: 30191999
Roder et al (2014) ANG-2 for quantitative Na(+) determination in living cells by time-resolved fluorescence microscopy. Photochem.Photobiol.Sci. 13 1699 PMID: 25311309
If you know of a relevant reference for ING-2 AM, please let us know.
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Fluorescent Dyes and Probes Research Product Guide
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