Home / Pharmacology / Enzymes / Demethylases / Histone Demethylases / Histone Demethylase Inhibitors / IOX 1

IOX 1

Cat. No. 4464 3 Citations Submit a Review Datasheet / COA / SDS
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Description: Histone demethylase inhibitor; cell permeable
Alternative Names: 5-carboxy-8HQ
Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for IOX 1

IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.

Compound Libraries for IOX 1

IOX 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for IOX 1

M. Wt 189.17
Formula C10H7NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 5852-78-8
PubChem ID 459617
InChI Key JGRPKOGHYBAVMW-UHFFFAOYSA-N
Smiles OC2=CC=C(C(O)=O)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IOX 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.92 100
1eq. NaOH 18.92 100

Preparing Stock Solutions for IOX 1

The following data is based on the product molecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.29 mL 26.43 mL 52.86 mL
5 mM 1.06 mL 5.29 mL 10.57 mL
10 mM 0.53 mL 2.64 mL 5.29 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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References for IOX 1

References are publications that support the biological activity of the product.

King et al (2010) Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One. 5 e15535 PMID: 21124847

Hu et al (2022) Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. EBioMedicine 86 104333 PMID: 36335665

If you know of a relevant reference for IOX 1, please let us know.

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View all Histone Demethylase Inhibitors

Keywords: IOX 1, IOX 1 supplier, IOX1, histone, demethylases, inhibitors, inhibits, JMJD2, JMJD3, JMJD6, JMJD1, UTX, H3K9me3, demethylation, demethylates, cell, permeable, in, vitro, activity, sgc, T, cells, anti-inflammatory, Th17, IL-17, 5-carboxy-8HQ, Histone, Demethylases, 4464, Tocris Bioscience

3 Citations for IOX 1

Citations are publications that use Tocris products. Selected citations for IOX 1 include:

Li et al (2018) Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun 9 1420 PMID: 29650963

Sandra et al (2021) A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival. Cell Death Dis 12 573 PMID: 34083515

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

Do you know of a great paper that uses IOX 1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.