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Description: Dual BRD4 and CBP/p300 bromodomain inhibitor
Chemical Name: [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine
Purity: ≥98% (HPLC)
Biological Activity for ISOX DUAL
ISOX DUAL is a dual CBP/p300 and BRD4 bromodomain inhibitor (IC50 values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for ISOX DUAL
| M. Wt | 531.69 |
| Formula | C31H41N5O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1962928-22-8 |
| PubChem ID | 121237857 |
| InChI Key | HCDQWCDANVEBQR-UHFFFAOYSA-N |
| Smiles | CC(ON=C1C)=C1C2=CC(N=C(CCC3=CC=C(OCCCN(C)C)C=C3)N4CCN5CCOCC5)=C4C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ISOX DUAL
References for ISOX DUAL
References are publications that support the biological activity of the product.
Chekler (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588 PMID: 26670081
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Keywords: ISOX DUAL, ISOX DUAL supplier, Dual, CBP/p300, BRD4, bromodomains, inhibitors, inflammation, macrophages, inhibits, Bromodomains, Histone, Acetyltransferases, 5806, Tocris Bioscience
Citations for ISOX DUAL
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