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IT 901

Cat. No. 5846 Submit a Review Datasheet / COA / SDS

Discontinued Product

5846 has been discontinued.

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Description: NF-κB c-Rel subunit inhibitor
Chemical Name: 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for IT 901

IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. Reduces severity of graft-versus-host disease following hematopoietic stem cell transplant (HSCT) and inhibits growth of human B-cell lymphoma xenografts in mice. Inhibits the oxidative stress response in lymphoma cells.

Technical Data for IT 901

M. Wt 342.37
Formula C17H14N2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1584121-99-2
PubChem ID 90082813
InChI Key JHOPCCOYRKEHQU-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C2)C2=C(/C=C3C(NC(NC/3=O)=S)=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for IT 901

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for IT 901

References are publications that support the biological activity of the product.

Shono et al (2016) Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses. Cancer Res. 76 377 PMID: 26744524

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Citations for IT 901

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Pathways for IT 901

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.