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Description: USP14 inhibitor
Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Purity: ≥98% (HPLC)
Biological Activity for IU1
Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.
Technical Data for IU1
| M. Wt | 300.37 |
| Formula | C18H21FN2O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 314245-33-5 |
| PubChem ID | 675434 |
| InChI Key | JUWDSDKJBMFLHE-UHFFFAOYSA-N |
| Smiles | O=C(CN2CCCC2)C1=C(C)N(C3=CC=C(F)C=C3)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for IU1
References for IU1
References are publications that support the biological activity of the product.
Lee et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467 179 PMID: 20829789
Lee et al (2010) Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol.Cell.Proteomics 10 R110 PMID: 20823120
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Keywords: IU1, IU1 supplier, selective, usp14, inhibitors, inhibits, proteasome, substrate, degradation, Deubiquitinating, Enzymes, 4088, Tocris Bioscience
Citations for IU1
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