Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewJWH 133 (in Tocrisolve™ 100)
Description: Potent, selective CB2 agonist (in water-soluble emulsion)
Chemical Name: (6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Biological Activity for JWH 133 (in Tocrisolve™ 100)
Potent CB2 selective agonist (Ki = 3.4 nM), in water-soluble emulsion (for details see TocrisolveTM 100). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis.
JWH 133 available as a solid.
Technical Data for JWH 133 (in Tocrisolve™ 100)
| M. Wt | 312.49 |
| Formula | C22H32O |
| Storage | Store at +4°C |
| CAS Number | 259869-55-1 |
| PubChem ID | 6918505 |
| InChI Key | YSBFLLZNALVODA-RBUKOAKNSA-N |
| Smiles | [H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JWH 133 (in Tocrisolve™ 100)
References for JWH 133 (in Tocrisolve™ 100)
References are publications that support the biological activity of the product.
Baker et al (2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404 84 PMID: 10716447
Huffman et al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595
Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884
View Related Products by Target
View Related Products by Product Action
Keywords: JWH 133 (in Tocrisolve 100), JWH 133 (in Tocrisolve 100) supplier, Potent, selective, CB2, agonists, water-soluble, emulsion, cannabinoids, Receptors, JWH133, cb2r, 1783, Tocris Bioscience
1 Citation for JWH 133 (in Tocrisolve™ 100)
Citations are publications that use Tocris products. Selected citations for JWH 133 (in Tocrisolve™ 100) include:
Williams et al (2014) △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. Autophagy 9 369 PMID: 24562630
Reviews for JWH 133 (in Tocrisolve™ 100)
There are currently no reviews for this product. Be the first to review JWH 133 (in Tocrisolve™ 100) and earn rewards!
Have you used JWH 133 (in Tocrisolve™ 100)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.