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Description: Kinesin-1 modulator; cell permeable
Chemical Name: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
Purity: ≥98% (HPLC)
Biological Activity for Kinesore
Kinesore is a kinesin-1 modulator. Inhibits SKIP-KLC2 interaction, but promotes kinesin-1 function in controlling the organization of the microtubule network. Induces remodeling of the microtubule network and the formation of extensive microtubule-rich projections. Cell permeable.
Technical Data for Kinesore
| M. Wt | 536.17 |
| Formula | C20H16Br2N4O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 363571-83-9 |
| PubChem ID | 5507411 |
| InChI Key | DUGCMEGLYHBMAR-RMORIDSASA-N |
| Smiles | CC1=CC(/C=N/NC(C2=CC(Br)=C(C(Br)=C2)O)=O)=C(N1C3=CC([N+]([O-])=O)=CC=C3)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kinesore
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.62 | 100 |
Preparing Stock Solutions for Kinesore
The following data is based on the product molecular weight 536.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.87 mL | 9.33 mL | 18.65 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.73 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.87 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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Product Datasheets for Kinesore
References for Kinesore
References are publications that support the biological activity of the product.
Randall et al (2017) A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Proc.Natl.Acad.Sci.USA 114 13743 PMID: 29229862
If you know of a relevant reference for Kinesore, please let us know.
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Keywords: Kinesore, Kinesore supplier, Kinesin-1, modulators, modulates, SKIP-KLC2, microtubule, remodeling, cell, permeable, Kinesin, 6664, Tocris Bioscience
Citations for Kinesore
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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