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Submit ReviewKRCA 0008
Description: Potent Ack1 and ALK dual inhibitor; orally bioavailable
Chemical Name: 1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone
Purity: ≥99% (HPLC)
Biological Activity for KRCA 0008
KRCA 0008 is a potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.
Technical Data for KRCA 0008
| M. Wt | 609.12 |
| Formula | C30H37ClN8O4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1472795-20-2 |
| PubChem ID | 72547474 |
| InChI Key | TXDIRJCYNAWBOS-UHFFFAOYSA-N |
| Smiles | ClC1=C(NC2=C(OC)C=C(N3CCN(C(C)=O)CC3)C=C2)N=C(NC4=CC=C(N5CCN(C(C)=O)CC5)C=C4OC)N=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for KRCA 0008
References for KRCA 0008
References are publications that support the biological activity of the product.
Park et al (2013) Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment. Bioorg.Med.Chem.Lett. 23 6192 PMID: 24095090
Lee et al (2014) ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment. Arch.Pharm.Res. 37 1130 PMID: 24446111
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Keywords: KRCA 0008, KRCA 0008 supplier, KRCA0008, Potent, anaplastic, lymphoma, kinase, ALK, Ack1, inhibitors, inhibits, antitumor, tyrosine, kinases, orally, bioavailable, TNK2, 5098, Tocris Bioscience
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