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L 012 sodium salt

Cat. No. 5085 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Chemiluminescent ROS and RNS indicator
Chemical Name: 8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for L 012 sodium salt

L 012 sodium salt is a luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.

Technical Data for L 012 sodium salt

M. Wt 310.67
Formula C13H8CIN4NaO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 143556-24-5
PubChem ID 78243715
InChI Key IGEUYSJHQQCEFP-UHFFFAOYSA-M
Smiles NC1=C3C(C(O[Na])=NNC3=O)=C(Cl)N=C1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L 012 sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.21 20
DMSO 31.07 100

Preparing Stock Solutions for L 012 sodium salt

The following data is based on the product molecular weight 310.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.09 mL 32.19 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Product Datasheets for L 012 sodium salt

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for L 012 sodium salt

References are publications that support the biological activity of the product.

Kielland et al (2009) In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic.Biol.Med. 47 760 PMID: 19539751

Zhou et al (2012) Noninvasive assessment of localized inflammatory responses. Free Radic.Biol.Med. 52 218 PMID: 22080048

Ichibangase et al (2013) Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2 O2. Luminescence. 29 118 PMID: 23630098

If you know of a relevant reference for L 012 sodium salt, please let us know.

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Keywords: L 012 sodium salt, L 012 sodium salt supplier, L012, sodium, salt, chemiluminescent, reactive, oxygen, nitrogen, species, fluorescent, probes, Fluorescent, Cell, Indicators, and, Sensors, Other, Nitric, Oxide, 5085, Tocris Bioscience

2 Citations for L 012 sodium salt

Citations are publications that use Tocris products. Selected citations for L 012 sodium salt include:

Jie et al (2020) IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain. Theranostics 10 12189-12203 PMID: 33204337

Mentrup et al (2022) Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nat.Commun. 13 1880 PMID: 35388002

Do you know of a great paper that uses L 012 sodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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