L-152,804

Pricing Availability   Qty
Description: Potent, selective non-peptide NPY Y5 receptor antagonist
Chemical Name: 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews
Literature (1)

Biological Activity for L-152,804

L-152,804 is a potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.

Technical Data for L-152,804

M. Wt 366.46
Formula C23H26O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 6508-43-6
PubChem ID 3765615
InChI Key XQDXIHYKAGHZRX-UHFFFAOYSA-N
Smiles CC1(C)CC(=O)C(C2C3=C(OC4=C2C(=O)CC(C)(C)C4)C=CC=C3)C(=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-152,804

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.65 100

Preparing Stock Solutions for L-152,804

The following data is based on the product molecular weight 366.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.64 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for L-152,804

References are publications that support the biological activity of the product.

Kanatani et al (2000) L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem.Biophys.Res.Commun. 272 169 PMID: 10872822

Mashiko et al (2007) A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol.Pharmacol. 71 602 PMID: 17105869

Schroeder et al (2005) The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol 36 179 PMID: 16377459


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Keywords: L-152,804, L-152,804 supplier, Potent, selective, non-peptide, NPY, Y5, antagonists, Neuropeptide, Y, Receptors, L152804, neuropeptides, 1382, Tocris Bioscience

9 Citations for L-152,804

Citations are publications that use Tocris products. Selected citations for L-152,804 include:

Santos-Carvalho et al (2013) Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Neuropsychopharmacology 4 e636 PMID: 23681231

Woldbye et al (2010) Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures. Brain 133 2778 PMID: 20688813

Businaro et al (2018) Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep 8 14365 PMID: 30254326

Long et al (2015) Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Ins Resistance Partly via the Y5 Receptor. J Pharmacol Exp Ther 10 e0126714 PMID: 25993471


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.