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Submit ReviewL-732,138
Description: Potent and selective NK1 antagonist
Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
Purity: ≥98% (HPLC)
Biological Activity for L-732,138
L-732,138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for L-732,138
| M. Wt | 472.39 |
| Formula | C22H18F6N2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 148451-96-1 |
| PubChem ID | 44396853 |
| InChI Key | BYYQYXVAWXAYQC-LJQANCHMSA-N |
| Smiles | O=C(N[C@@](CC2=CNC3=C2C=CC=C3)([H])C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-732,138
References for L-732,138
References are publications that support the biological activity of the product.
Cascieri et al (1994) Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 269 6587 PMID: 7509807
Kuo et al (1998) Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 125 711 PMID: 9831906
MacLeod et al (1993) N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 36 2044 PMID: 8393115
MacLeod et al (1994) Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J.Med.Chem. 37 1269 PMID: 7513763
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Keywords: L-732,138, L-732,138 supplier, Potent, selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, L732138, merck, Receptor, 0868, Tocris Bioscience
2 Citations for L-732,138
Citations are publications that use Tocris products. Selected citations for L-732,138 include:
Wan et al (2017) Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci 9 167 PMID: 28119567
Li et al (2013) Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. J Neurosci 11 294 PMID: 23345604
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