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Lansoprazole

Cat. No. 2582 Submit a Review Datasheet / COA / SDS

Discontinued Product

2582 has been discontinued.

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Description: H+,K+-ATPase inhibitor
Alternative Names: AG-1749
Chemical Name: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
Purity: ≥99% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for Lansoprazole

Lansoprazole is a H+,K+-ATPase inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).

Technical Data for Lansoprazole

M. Wt 369.36
Formula C16H14F3N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103577-45-3
PubChem ID 3883
InChI Key MJIHNNLFOKEZEW-UHFFFAOYSA-N
Smiles CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Lansoprazole

References are publications that support the biological activity of the product.

Satoh et al (1989) Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360

Matheson and Jarvis (2001) Lansoprazole. Drugs 61 1801 PMID: 11693467

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Keywords: Lansoprazole, Lansoprazole supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, AG1749, AG-1749, H+,K+-ATPase, 2582, Tocris Bioscience

Citations for Lansoprazole

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