Home / Pharmacology / GPCRs / 7-TM Receptors / Prostanoid Receptors / Prostanoid Receptor Antagonists / Laropiprant

Laropiprant

Cat. No. 7343 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective prostaglandin D2 receptor antagonist
Chemical Name: (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Laropiprant

Laropiprant is a potent and selective prostaglandin D2 receptor antagonist (IC50 = 0.09 nM in washed platelets; Ki = 0.57). It exhibits selectivity for binding to PGD2 receptors over other prostanoid receptors (Ki values are ≥ 2.95 nM for TP, EP1, EP2, EP3, EP4, FP and IP). Laropiprant promotes coagulation of whole blood ex vivo and reduces bleeding time in mice in vivo. In a mouse model of intracerebral hemorrhage, Laropiprant reduces lesion volume and attenuates neurological deficit scores. The compound also reduces Niacin (Cat. No. 4106) induced vasodilation.

Compound Libraries for Laropiprant

Laropiprant is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Laropiprant

M. Wt 435.9
Formula C21H19ClFNO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 571170-77-9
PubChem ID 9867642
InChI Key NXFFJDQHYLNEJK-CYBMUJFWSA-N
Smiles C(N1C=2C(C3=C1[C@@H](CC(O)=O)CC3)=CC(F)=CC2S(C)(=O)=O)C4=CC=C(Cl)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Laropiprant

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.59 100
ethanol 21.8 50

Preparing Stock Solutions for Laropiprant

The following data is based on the product molecular weight 435.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.47 mL 22.94 mL
5 mM 0.46 mL 2.29 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Laropiprant

References are publications that support the biological activity of the product.

Sturino et al (2007) Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J.Med.Chem. 50 794 PMID: 17300164

Kong et al (2017) Niacin promotes cardiac healing after myocardial infarction through activation of the myeloid prostaglandin D2 receptor subtype 1. J.Pharmacol.Exp.Ther. 360 435 PMID: 28057839

Ahmad et al (2017) Efficacy of Laropiprant in minimizing brain injury following experimental intracerebral hemorrhage. Sci.Rep. 7 9489 PMID: 28842638

If you know of a relevant reference for Laropiprant, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Prostanoid Receptor Antagonists

Keywords: Laropiprant, Laropiprant supplier, prostaglandin, D2, receptor, antagonist, potent, selective, PGD2, DP, Prostanoid, Receptors, 7343, Tocris Bioscience

Citations for Laropiprant

Citations are publications that use Tocris products.

Currently there are no citations for Laropiprant. Do you know of a great paper that uses Laropiprant from Tocris? Please let us know.

Reviews for Laropiprant

There are currently no reviews for this product. Be the first to review Laropiprant and earn rewards!

Have you used Laropiprant?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review