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Submit ReviewLavendustin A
Description: EGFR, p60c-src inhibitor
Alternative Names: RG 14355
Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid
Purity: ≥98% (HPLC)
Biological Activity for Lavendustin A
Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).
Technical Data for Lavendustin A
| M. Wt | 381.38 |
| Formula | C21H19NO6 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 125697-92-9 |
| PubChem ID | 3894 |
| InChI Key | ULTTYPMRMMDONC-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(O)C=C1CN(CC3=C(O)C=CC=C3)C2=CC=C(O)C(C(O)=O)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Lavendustin A
References for Lavendustin A
References are publications that support the biological activity of the product.
Hsu et al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105 PMID: 1939153
O'Dell et al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558 PMID: 1656271
Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252 PMID: 2614420
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Keywords: Lavendustin A, Lavendustin A supplier, EGFR, p60c-src, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, LavendustinA, RG14355, RG, 14355, Src, 1331, Tocris Bioscience
Citations for Lavendustin A
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