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Submit ReviewLDN 57444
Description: Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor
Chemical Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
Purity: ≥98% (HPLC)
Biological Activity for LDN 57444
LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.
Technical Data for LDN 57444
| M. Wt | 397.64 |
| Formula | C17H11Cl3N2O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 668467-91-2 |
| PubChem ID | 24906255 |
| InChI Key | OPQRFPHLZZPCCH-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N(CC3=CC(Cl)=CC=C3Cl)C(C2=NOC(C)=O)=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LDN 57444
References for LDN 57444
References are publications that support the biological activity of the product.
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054
Tan et al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318 109 PMID: 18622688
Cartier et al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci. 29 7857 PMID: 19535597
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Keywords: LDN 57444, LDN 57444 supplier, LDN57444, UCH, L1, inhibitors, inhibits, ubiquitin, C-terminal, hydrolases, UCH-L1, Deubiquitinating, Enzymes, 3998, Tocris Bioscience
1 Citation for LDN 57444
Citations are publications that use Tocris products. Selected citations for LDN 57444 include:
Zlatic et al (2018) Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees. Cell Syst 6 368 PMID: 29397366
Reviews for LDN 57444
Average Rating: 4 (Based on 1 Review.)
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Culture with LDN57444.
By
Anonymous on 12/10/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Fibroblasts
Basal oxygen consumption rates were collected for 4 hours following the addition of CuCl2, LDN57444
