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Submit Review[Leu31,Pro34]-Neuropeptide Y (human, rat)
Description: NPY Y1 receptor agonist
Alternative Names: [Leu31,Pro34]-NPY (human)
Purity: ≥95% (HPLC)
Biological Activity
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.
Technical Data
| M. Wt | 4241 |
| Formula | C189H284N54O56S |
| Sequence |
YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY (Modifications: Tyr-36 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 132699-73-1 |
| PubChem ID | 24868223 |
| InChI Key | MPWANDCMSKOYBR-MJWITIMHSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911
Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182 PMID: 2153286
Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507 PMID: 9723965
Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761
If you know of a relevant reference for [Leu31,Pro34]-Neuropeptide Y (human, rat), please let us know.
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Keywords: [Leu31,Pro34]-Neuropeptide Y (human, rat), [Leu31,Pro34]-Neuropeptide Y (human, rat) supplier, NPY, Y1, receptor, agonists, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (human,, rat), neuropeptides, [Leu31,Pro34]-NPY, (human), 1176, Tocris Bioscience
3 Citations for [Leu31,Pro34]-Neuropeptide Y (human, rat)
Citations are publications that use Tocris products. Selected citations for [Leu31,Pro34]-Neuropeptide Y (human, rat) include:
Malet (2017) Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury. Peptides 92 38 PMID: 28465077
Maymon et al (2019) Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. Neuropharmacology 162 PMID: 31622603
Yu et al (2016) Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling. Int J Mol Sci 17 PMID: 28009825
Do you know of a great paper that uses [Leu31,Pro34]-Neuropeptide Y (human, rat) from Tocris? Please let us know.
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[Leu31,Pro34]-Neuropeptide Y current in spinal dorsal horn neuron.
By
Allen Dickie on 03/24/2023
Assay Type: Ex Vivo
Species: Mouse
Whole cell patch clamp recording (voltage clamp) from spinal dorsal horn interneuron, in ex vivo slice preparation, in response to bath application of [Leu31,Pro34]-Neuropeptide Y (300 nM), in the presence of TTX, bicuculline and strychnine.
Literature in this Area
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