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Submit Review[Leu31,Pro34]-Neuropeptide Y (porcine)
Description: NPY Y1 receptor agonist
Alternative Names: [Leu31,Pro34]-NPY (porcine)
Biological Activity for [Leu31,Pro34]-Neuropeptide Y (porcine)
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.54 nM). Also shows affinity for Y5 receptors.
Technical Data for [Leu31,Pro34]-Neuropeptide Y (porcine)
| M. Wt | 4223 |
| Formula | C190H286N54O56 |
| Sequence |
YPSKPDNPGEDAPAEDLARYYSALRHYINLLTRPRY (Modifications: Tyr-36 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 125580-28-1 |
| PubChem ID | 16136687 |
| InChI Key | ZNBZLZXDILRJJT-CCPZSHQESA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Leu31,Pro34]-Neuropeptide Y (porcine)
References for [Leu31,Pro34]-Neuropeptide Y (porcine)
References are publications that support the biological activity of the product.
Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911
Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182 PMID: 2153286
Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507 PMID: 9723965
Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761
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Keywords: [Leu31,Pro34]-Neuropeptide Y (porcine), [Leu31,Pro34]-Neuropeptide Y (porcine) supplier, NPY, Y1, receptor, agonist, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (porcine), neuropeptides, [Leu31,, Pro34]-NPY, 1168, Tocris Bioscience
Citations for [Leu31,Pro34]-Neuropeptide Y (porcine)
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.