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Submit ReviewLU AA33810
Description: Potent NPY Y5 receptor antagonist
Chemical Name: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for LU AA33810
LU AA33810 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
Compound Libraries for LU AA33810
LU AA33810 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for LU AA33810
| M. Wt | 423.62 |
| Formula | C19H25N3O2S3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 304008-29-5 |
| PubChem ID | 22254068 |
| InChI Key | UWSBTSAJZMIHBL-UHFFFAOYSA-N |
| Smiles | O=S(NC[C@H](CC4)CC[C@@H]4NC1=NC(C2=CC=CC=C2SCC3)=C3S1)(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LU AA33810
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.36 | 100 |
Preparing Stock Solutions for LU AA33810
The following data is based on the product molecular weight 423.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.36 mL | 11.8 mL | 23.61 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for LU AA33810
References for LU AA33810
References are publications that support the biological activity of the product.
Walker et al (2009) The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects J.Pharmacol.Exp.Ther. 328 900 PMID: 19098165
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Keywords: LU AA33810, LU AA33810 supplier, LUAA33810, potent, NPY, neuropeptide, Y, receptors, Y5, antagonists, neuropeptides, Receptors, 3562, Tocris Bioscience
Citations for LU AA33810
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.