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Submit ReviewMethylnaltrexone bromide
Discontinued Product
6109 has been discontinued.
Description: μ antagonist; peripherally restricted
Chemical Name: 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide
Purity: ≥98% (HPLC)
Biological Activity for Methylnaltrexone bromide
Methylnaltrexone bromide is a peripherally restricted μ-opioid antagonist. Antagonizes the effects of morphine (Cat. No. 5158) on contraction of isolated guinea pig ileum. Quaternary derivative of naltrexone (Cat. No. 0677).
Technical Data for Methylnaltrexone bromide
| M. Wt | 436.34 |
| Formula | C21H26BrNO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 73232-52-7 |
| PubChem ID | 5361917 |
| InChI Key | IFGIYSGOEZJNBE-KNLJMPJLSA-N |
| Smiles | O=C1[C@H]2C34C5=C(O2)C(O)=CC=C5CC([N+](CC6CC6)(C)CC4)[C@]3(O)CC1.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Methylnaltrexone bromide
References for Methylnaltrexone bromide
References are publications that support the biological activity of the product.
Valentino et al (1981) Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists. J.Pharmacol.Exp.Ther. 217 652 PMID: 6262493
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Keywords: Methylnaltrexone bromide, Methylnaltrexone bromide supplier, peripheral, opioid, antagonists, antagonism, mu, receptor, Mu, Opioid, Receptors, 6109, Tocris Bioscience
Citations for Methylnaltrexone bromide
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