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Submit ReviewMitoglitazone
Discontinued Product
5799 has been discontinued.
View all Insulin and Insulin-like Receptors products.
Description: Insulin sensitizer; exhibits low binding affinity at PPARγ
Alternative Names: CAY 10415,MSDC 0160
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Biological Activity for Mitoglitazone
Mitoglitazone is an insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).
Technical Data for Mitoglitazone
| M. Wt | 370.42 |
| Formula | C19H18N2O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 146062-49-9 |
| PubChem ID | 10429242 |
| InChI Key | IRNJSRAGRIZIHD-UHFFFAOYSA-N |
| Smiles | CCC1=CC=C(C(COC2=CC=C(C=C2)CC3SC(NC3=O)=O)=O)N=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Mitoglitazone
References for Mitoglitazone
References are publications that support the biological activity of the product.
Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422 PMID: 23513224
Chen et al (2012) Ins resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537 PMID: 22621923
Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione Ins sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551 PMID: 23690925
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Keywords: Mitoglitazone, Mitoglitazone supplier, Antidiabetic, neurodegeneration, Alzheimer's, Parkinson's, diseases, mTOT, target, thiazolidinones, insulin, resistance, mitochondria, metabolism, pyruvate, carriers, MPC, hyperglycemia, CAY, 10415, MSDC, 0160, Insulin, and, insulin-like, Receptors, Insulin-like, PPARgamma, 5799, Tocris Bioscience
Citations for Mitoglitazone
Citations are publications that use Tocris products.
Currently there are no citations for Mitoglitazone.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for Mitoglitazone
