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ML 130

Cat. No. 4354 Submit a Review Datasheet / COA / SDS

Discontinued Product

4354 has been discontinued.

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Description: Inhibits NOD1-induced NF-κB activation
Chemical Name: 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
Purity: ≥99% (HPLC)
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Citations
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Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for ML 130

ML 130 is a potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.

Compound Libraries for ML 130

ML 130 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 130

M. Wt 287.34
Formula C14H13N3O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 799264-47-4
PubChem ID 1088438
InChI Key SRFABRWQVPCPRG-UHFFFAOYSA-N
Smiles NC2=NC1=CC=CC=C1N2S(=O)(C3=CC=C(C)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ML 130

References are publications that support the biological activity of the product.

Correa et al (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem.Biol. 18 825 PMID: 21802003

Khan et al (2011) Identification of inhibitors of NOD1-induced nuclear factor-κB activation. ACS Med.Chem.Lett. 2 780 PMID: 22003428

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Citations for ML 130

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Pathways for ML 130

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.