Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 133 hydrochloride
Description: Kir2 channel blocker
Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ML 133 hydrochloride
ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).
Technical Data for ML 133 hydrochloride
| M. Wt | 313.82 |
| Formula | C19H19NO.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1222781-70-5 |
| PubChem ID | 44247466 |
| InChI Key | NGQIBUUFXDPHKT-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3CNCC1=C(C=CC=C2)C2=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 133 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.38 | 100 |
Preparing Stock Solutions for ML 133 hydrochloride
The following data is based on the product molecular weight 313.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.19 mL | 15.93 mL | 31.87 mL |
| 5 mM | 0.64 mL | 3.19 mL | 6.37 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.19 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ML 133 hydrochloride
References for ML 133 hydrochloride
References are publications that support the biological activity of the product.
Wang et al (2011) Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 6 845 PMID: 21615117
Wu et al (2010) A potent and selective small molecule Kir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro PMID: 21433384
If you know of a relevant reference for ML 133 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 133 hydrochloride, ML 133 hydrochloride supplier, ML133, hydrochloride, Kir2, Kir2.x, Kir2.1, Kir2.6, Kir2.2, Kir2.3, inhibitors, inhibits, inward, rectifier, potassium, channels, IRK1, KCNJ2, IRK2, hIRK, IRK3, hIRK2, Inward, Potassium, Channels, 4549, Tocris Bioscience
4 Citations for ML 133 hydrochloride
Citations are publications that use Tocris products. Selected citations for ML 133 hydrochloride include:
Lively et al (2018) Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. Front Cell Neurosci 12 115 PMID: 29780305
Lam and Schlichter (2015) Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Nat Commun 9 185 PMID: 26029054
Sung-Joong et al (2021) Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model. Int J Mol Sci 22 PMID: 34202215
Siddiqui et al (2016) Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation 13 66 PMID: 27009332
Do you know of a great paper that uses ML 133 hydrochloride from Tocris? Please let us know.
Reviews for ML 133 hydrochloride
Average Rating: 5 (Based on 1 Review.)
Have you used ML 133 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
ML 133 hydrochloride was used on Calcium-activated 6T & 1P potassium channels.
By
Anonymous on 02/27/2019
Species: Human
ML 133 hydrochloride was used on Calcium-activated 6T & 1P potassium channels. The product works ideally on cell culture labs and would highly recommend.
