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MLN 4760

Cat. No. 3345 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
Chemical Name: N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MLN 4760

MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC50 = 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation.

Technical Data for MLN 4760

M. Wt 428.31
Formula C19H23Cl2N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 305335-31-3
PubChem ID 448281
InChI Key NTCCRGGIJNDEAB-UHFFFAOYSA-N
Smiles ClC1=CC(CN2C(C[C@H](N[C@@H](CC(C)C)C(O)=O)C(O)=O)=CN=C2)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MLN 4760

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.83 100

Preparing Stock Solutions for MLN 4760

The following data is based on the product molecular weight 428.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.35 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References for MLN 4760

References are publications that support the biological activity of the product.

Mores et al (2008) Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 51 2216 PMID: 18324760

Sodhi et al (2019) A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 203 3000 PMID: 31645418

If you know of a relevant reference for MLN 4760, please let us know.

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Citations for MLN 4760

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