Home / Cell Biology / Signal Transduction / Cytokine and NF-κB Signaling / NF-κB and IκB / NF-κB and IκB Inhibitors / NIKi

NIKi

Cat. No. 7136 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent NIK inhibitor
Chemical Name: 4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol
Purity: ≥98%
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NIKi

NIKi is a potent inhibitor of NF-κB-inducing kinase (NIK) activity (IC50 = 20 nM).

Technical Data for NIKi

M. Wt 366.42
Formula C20H22N4O3
Storage Store at -20°C
Purity ≥98%
CAS Number 1202763-91-4
PubChem ID 58221375
InChI Key ZZIZLABGKZWVAW-UHFFFAOYSA-N
Smiles COCCOC1=CN=C(N=C1C2=CNC3=CC=C(C#CC(C)(O)C)C=C23)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NIKi

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.64 100

Preparing Stock Solutions for NIKi

The following data is based on the product molecular weight 366.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for NIKi

References are publications that support the biological activity of the product.

Li et al (2013) Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg.Med.Chem.Lett. 23 1238 PMID: 23374866

If you know of a relevant reference for NIKi, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: NIKi, NIKi supplier, potent, NF-κB, nf-kappab, nf-κb, blocks, inhibitors, inhibits, nuclear, factor, kappa, B, anti-inflammatory, antitumor, antitumour, NF-kB/IkB, 7136, Tocris Bioscience

Citations for NIKi

Citations are publications that use Tocris products.

Currently there are no citations for NIKi. Do you know of a great paper that uses NIKi from Tocris? Please let us know.

Reviews for NIKi

There are currently no reviews for this product. Be the first to review NIKi and earn rewards!

Have you used NIKi?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for NIKi

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.