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Description: Nrf2 activator
Chemical Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Purity: ≥98% (HPLC)
Biological Activity for NK 252
NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.
Compound Libraries for NK 252
NK 252 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NK 252
| M. Wt | 285.26 |
| Formula | C13H11N5O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1414963-82-8 |
| PubChem ID | 71618700 |
| InChI Key | FNSCFQXZZNCDAI-UHFFFAOYSA-N |
| Smiles | O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NK 252
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 28.53 | 100 | |
| DMSO | 28.53 | 100 |
Preparing Stock Solutions for NK 252
The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for NK 252
References for NK 252
References are publications that support the biological activity of the product.
Shimozono et al (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 84 62 PMID: 23592516
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Keywords: NK 252, NK 252 supplier, NK252, NRF2, activators, activates, Keap1, Nrf2, 5293, Tocris Bioscience
1 Citation for NK 252
Citations are publications that use Tocris products. Selected citations for NK 252 include:
Vladimir et al (2021) A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48 102186 PMID: 34801863
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