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Discontinued Product
2919 has been discontinued.
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Description: Caged fluorescent pH indicator
Chemical Name: 8-Hydroxypyrene-1,3,6-tris-sulfonic acid-8-1-(2-nitrophenyl)ethyl ether
Purity: ≥97% (HPLC)
Biological Activity for NPE-caged-HPTS
NPE-caged-HPTS is a caged fluorescent pH indicator. Rapidly releases the fluorophore HPTS (pyranine) (pKa 7.25) upon two-photon excitation (>3000 s-1). Routinely used for photolysis calibration. Suitable for use in small-compartment diffusion studies.
Technical Data for NPE-caged-HPTS
| M. Wt | 673.53 |
| Formula | C24H14NO12Na3S3 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 223759-19-1 |
| PubChem ID | 56972217 |
| InChI Key | CRGABPHUJQWBOR-UHFFFAOYSA-K |
| Smiles | [Na+].[Na+].[Na+].CC(OC1=C2C=CC3=C4C(C=CC(=C24)C(=C1)S([O-])(=O)=O)=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)C1=CC=CC=C1[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NPE-caged-HPTS
References for NPE-caged-HPTS
References are publications that support the biological activity of the product.
Willoughby et al (1998) Comparisons of simultaneous pH measurements made with 8-hydroxypyrene-1,3,6-trisulphonic acid (HPTS) and pH-sensitive microelectrodes in snail neurones. Pflugers Arch. 436 615 PMID: 9683736
Jasuja et al (1999) Chemotactic responses of Escherichia coli to small jumps of photoreleased L-aspartate. Biophys.J. 76 1706 PMID: 10049350
Kiskin et al (2002) The efficiency of two-photon photolysis of a "caged " fluorophore, o-1-(2-nitrophenyl)ethylpyranine, in relation to photodamage of synaptic terminals. Eur.Biophys.J. 30 588 PMID: 11908850
Bloodgood and Sabatini (2005) Neuronal activity regulates diffusion across the neck of dendritic spines. Science 310 866 PMID: 16272125
Trigo et al (2009) Laser photolysis of caged compounds at 405 nm: photochemical advantages, localisation, phototoxicity and methods for calibration. J.Neurosci.Methods 180 9 PMID: 19427524
Canepari et al (2001) Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters. J.Neurosci.Methods. 112 29 PMID: 11640955
Soler-Llavina et al (2006) Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. Nat.Neurosci. 9 798 PMID: 16680164
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Keywords: NPE-caged-HPTS, NPE-caged-HPTS supplier, Caged, fluorescent, pH, indicator, Fluorescent, Probes, Compounds, Ion, Indicators, Other, Cell, and, Sensors, 2919, Tocris Bioscience
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