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Submit ReviewNVS-CECR2-1
Description: Potent and selective CECR2 inhibitor
Chemical Name: N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine
Purity: ≥98% (HPLC)
Biological Activity for NVS-CECR2-1
NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC50 = 47 nM). Selective for CECR2 over a panel of bromodomains.
A concentration of 1 μM is recommended for use in cellular assays.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS-CECR2-1 probe summary on the SGC website.
Compound Libraries for NVS-CECR2-1
NVS-CECR2-1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for NVS-CECR2-1
| M. Wt | 495.68 |
| Formula | C27H37N5O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1992047-61-6 |
| PubChem ID | 117072550 |
| InChI Key | XVECNLUKQDKOST-UHFFFAOYSA-N |
| Smiles | CC(C1)(C)NC(C)(C)CC1N2C=CC3=C2C=CC(C4=NC(S(=O)(CCC)=O)=NC(NC5CC5)=C4)=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NVS-CECR2-1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.57 | 100 |
Preparing Stock Solutions for NVS-CECR2-1
The following data is based on the product molecular weight 495.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.09 mL | 20.17 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.03 mL |
| 10 mM | 0.2 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for NVS-CECR2-1
References for NVS-CECR2-1
References are publications that support the biological activity of the product.
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Keywords: NVS-CECR2-1, NVS-CECR2-1 supplier, Potent, selective, CECR2, cat, eye, syndrome, chromosome, region, candidate, 2, inhibitors, inhibits, bromodomains, Bromodomains, 5744, Tocris Bioscience
Citations for NVS-CECR2-1
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