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Submit ReviewONO 4817
Description: Broad spectrum MMP inhibitor
Chemical Name: N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
Purity: ≥99% (HPLC)
Biological Activity for ONO 4817
Broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μM. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.
Technical Data for ONO 4817
| M. Wt | 416.47 |
| Formula | C22H28N2O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 223472-31-9 |
| PubChem ID | 9888141 |
| InChI Key | HDWWQELUBWGQGA-WMZOPIPTSA-N |
| Smiles | O=C(N[C@H](COCOCC)C[C@H](C)C(NO)=O)C1=CC=C(OC2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ONO 4817
References for ONO 4817
References are publications that support the biological activity of the product.
Yamada et al (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm.Res. 49 144 PMID: 10858013
Muraishi et al (2001) Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma. Anticancer Res. 21 3845 PMID: 11911256
Medina and Radomski (2006) Role of matrix metalloproteinases in intestinal inflammation. J.Pharmacol.Exp.Ther. 318 933 PMID: 16644899
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Keywords: ONO 4817, ONO 4817 supplier, Broad, spectrum, MMP, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, ONO4817, 2628, Tocris Bioscience
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