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Submit ReviewPaprotrain
Description: Reversible inhibitor of MKLP-2
Chemical Name: (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Purity: ≥99% (HPLC)
Biological Activity for Paprotrain
Paprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.
Technical Data for Paprotrain
| M. Wt | 245.28 |
| Formula | C16H11N3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 57046-73-8 |
| PubChem ID | 12248889 |
| InChI Key | YMYYQRZCCKBFBE-MDWZMJQESA-N |
| Smiles | N#C/C(C3=CNC2=CC=CC=C23)=C\C1=CN=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Paprotrain
References for Paprotrain
References are publications that support the biological activity of the product.
Tcherniuk et al (2010) Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 49 8228 PMID: 20857469
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Keywords: Paprotrain, Paprotrain supplier, inhibitors, inhibits, MKLP-2, mitotic, kinesin-like, protein, 2, reversible, selective, Kinesin, 4813, Tocris Bioscience
Citations for Paprotrain
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Currently there are no citations for Paprotrain.
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets