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PD 166793

Cat. No. 2520 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Broad spectrum MMP inhibitor
Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PD 166793

PD 166793 is a broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Compound Libraries for PD 166793

PD 166793 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 166793

M. Wt 412.3
Formula C17H18BrNO4S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 199850-67-4
PubChem ID 9887870
InChI Key GJOCABIDMCKCEG-INIZCTEOSA-N
Smiles BrC1=CC=C(C2=CC=C(S(N[C@@H]([C@H](C)C)C(O)=O)(=O)=O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PD 166793

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.23 100
ethanol 41.23 100

Preparing Stock Solutions for PD 166793

The following data is based on the product molecular weight 412.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.13 mL 24.25 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for PD 166793

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for PD 166793

References are publications that support the biological activity of the product.

O'Brien et al (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 43 156 PMID: 10649971

Peterson et al (2001) Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 103 2303 PMID: 11342481

Chancey et al (2002) Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 105 1983 PMID: 11997287

If you know of a relevant reference for PD 166793, please let us know.

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Keywords: PD 166793, PD 166793 supplier, Broad, spectrum, MMP, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, PD166793, 2520, Tocris Bioscience

1 Citation for PD 166793

Citations are publications that use Tocris products. Selected citations for PD 166793 include:

Bencsik et al (2018) Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection. Front Pharmacol 9 296 PMID: 29674965

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Literature in this Area

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