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Description: Activator of caspase-3
Chemical Name: α-(Trichloromethyl)-4-pyridineethanol
Purity: ≥99% (HPLC)
Biological Activity for PETCM
PETCM is a caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
Technical Data for PETCM
| M. Wt | 240.52 |
| Formula | C8H8Cl3NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 10129-56-3 |
| PubChem ID | 224859 |
| InChI Key | NGTDJJKTGRNNAU-UHFFFAOYSA-N |
| Smiles | OC(CC1=CC=NC=C1)C(Cl)(Cl)Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PETCM
References for PETCM
References are publications that support the biological activity of the product.
Jiang et al (2003) Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299 223 PMID: 12522243
Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.U.S.A. 100 7533 PMID: 12808146
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Keywords: PETCM, PETCM supplier, activators, caspase-3, Caspases, Proteinases, Proteases, Enzyme, Substrates, /, Activators, 1758, Tocris Bioscience
Citations for PETCM
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Currently there are no citations for PETCM.
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Literature in this Area
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