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Submit ReviewPF 3716556
Discontinued Product
4191 has been discontinued.
View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.
Description: Selective H+,K+-ATPase inhibitor
Chemical Name: 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for PF 3716556
PF 3716556 is a H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays); more potent in acidic conditions. Highly selective for H+,K+-ATPase in vitro; displays no activity at Na+,K+-ATPase. Also displays selectivity for H+,K+-ATPase over a range of 50 receptors and ion channels (IC50 > 10 μM). Inhibits gastric acid secretion in rat and dog models.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 3716556
| M. Wt | 394.47 |
| Formula | C22H26N4O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 928774-43-0 |
| PubChem ID | 25134521 |
| InChI Key | YBHKBMJREUZHOV-QGZVFWFLSA-N |
| Smiles | OCCN(C)C(C2=CN1C(C(N[C@H]4C3=C(C)C=CC=C3OCC4)=C2)=NC(C)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 3716556
References for PF 3716556
References are publications that support the biological activity of the product.
Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesop J.Pharmacol.Exp.Ther. 328 671 PMID: 18981288
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Keywords: PF 3716556, PF 3716556 supplier, selective, inhibitors, inhibits, H+K+-ATPase, hydrogen, potassium-ATPase, ion, transporters, pumps, ATPases, PF3716556, pfizer, H+,K+-ATPase, 4191, Tocris Bioscience
Citations for PF 3716556
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