Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPhaclofen
Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid
Purity: ≥97% (HPLC)
Biological Activity for Phaclofen
Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
Technical Data for Phaclofen
| M. Wt | 249.63 |
| Formula | C9H13ClNO3P |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 114012-12-3 |
| PubChem ID | 1641 |
| InChI Key | VSGNGLJPOGUDON-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Phaclofen
References for Phaclofen
References are publications that support the biological activity of the product.
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of bac. induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310
Kerr et al (1987) Phaclofen: a peripheral and central bac. antagonist. Brain Res. 405 150 PMID: 3032346
View Related Products by Target
View Related Products by Product Action
Keywords: Phaclofen, Phaclofen supplier, selective, GABAB, antagonists, Receptors, 0178, Tocris Bioscience
3 Citations for Phaclofen
Citations are publications that use Tocris products. Selected citations for Phaclofen include:
Dulcis et al (2017) Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron 95 1319 PMID: 28867550
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050 PMID: 11082110
Ibbotson et al (1997) Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. Br J Pharmacol 122 956 PMID: 9384515
Reviews for Phaclofen
There are currently no reviews for this product. Be the first to review Phaclofen and earn rewards!
Have you used Phaclofen?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.