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Submit ReviewPhaclofen
Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid
Purity: ≥97% (HPLC)
Biological Activity for Phaclofen
Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
Technical Data for Phaclofen
| M. Wt | 249.63 |
| Formula | C9H13ClNO3P |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 114012-12-3 |
| PubChem ID | 1641 |
| InChI Key | VSGNGLJPOGUDON-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Phaclofen
References for Phaclofen
References are publications that support the biological activity of the product.
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of bac. induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310
Kerr et al (1987) Phaclofen: a peripheral and central bac. antagonist. Brain Res. 405 150 PMID: 3032346
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Keywords: Phaclofen, Phaclofen supplier, selective, GABAB, antagonists, Receptors, 0178, Tocris Bioscience
3 Citations for Phaclofen
Citations are publications that use Tocris products. Selected citations for Phaclofen include:
Ibbotson et al (1997) Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. Br J Pharmacol 122 956 PMID: 9384515
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050 PMID: 11082110
Dulcis et al (2017) Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron 95 1319 PMID: 28867550
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.